Which sign is considered a clinical indication for administering sodium bicarbonate?

Sodium bicarbonate is commonly indicated for conditions where there is acidosis, particularly in cases of metabolic acidosis due to tissue hypoxia or specific medical conditions. In the context of crush syndrome, the release of intracellular potassium and hydrogen ions into the bloodstream can lead to hyperkalemia and acidosis as muscles are damaged and their contents spill into circulation. This acidosis must be managed to prevent complications like cardiac arrhythmias and systemic effects, making sodium bicarbonate a useful treatment option.

When administering sodium bicarbonate in the context of crush syndrome, it helps to neutralize the acidosis and manage elevated potassium levels by shifting potassium into cells, thus addressing both the acidosis and the potential for life-threatening hyperkalemia that often accompanies this condition.